منابع مشابه
Beyond apoptosis: nonapoptotic cell death in physiology and disease.
Apoptosis is a morphologically defined form of programmed cell death (PCD) that is mediated by the activation of members of the caspase family. Analysis of death-receptor signaling in lymphocytes has revealed that caspase-dependent signaling pathways are also linked to cell death by nonapoptotic mechanisms, indicating that apoptosis is not the only form of PCD. Under physiological and pathologi...
متن کامل[Apoptosis--programmed cell death].
Apoptosis is a highly organized physiologic mechanism of destroying injured and abnormal cells as well as maintaining homeostasis in the multicellular organism. Apoptosis is tightly controlled at the genetic level and dysregulation of the apoptosis machinery may contribute to a variety of diseases. Pharmacologic manipulation of this pathway is a novel therapeutic target.
متن کاملApoptosis: programmed cell death.
C urrently there is much interest and excitement in the understanding of how cells undergo the process of apoptosis or programmed cell death. Understanding how, why, and when cells are instructed to die may provide insight into the aging process, autoimmune syndromes, degenerative diseases, and malignant transformation. This review focuses on the development of apoptosis and describes the proce...
متن کاملApoptosis: cell ‘death’ reveals Creation
Apoptosis* (‘programmed cell death’) is a biologically ubiquitous phenomenon that deserves to be much more widely known among non-biologists and laypeople. Put quite simply, without apoptosis, all multicellular life would be impossible. From a creationist perspective, the vast literature that exists on this subject is seen to be entirely compatible with its origin as a created process. It is ge...
متن کاملApoptosis, Cell Death and Inflammation
ceptors (e.g. members of the TNF superfamily such as TNFR1, CD95 or Toll-like receptors [4] ), or the intracellular sensors, nucleotide-binding and oligomerization domain (NOD)-like receptors [5, 6] , all of which can instigate inflammatory responses and modulate the cell’s survival/death balance. NOD-like receptors can assemble into large multiprotein complexes, termed inflammasomes, which can...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2000
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2401864